The following are links to data we’ve published in the last 5 years. Click here to see all published data sets.
A single cell atlas of human adipose tissue
Design: Human samples: Excess adipose tissue from male and female subjects over the age of 18 undergoing elective plastic surgery procedures and free of other acute medical conditions was collected. Mouse samples: Male and female C57Bl/6J 16-week old high fat diet fed (JAX 380050) and chow fed (JAX 380056) mice were obtained from The Jackson Laboratory and maintained on 60% high fat diet or chow diet for three weeks before sacrifice.
Organism: Homo sapiens; Mus musculus
Type: Expression profiling by high throughput sequencing
50 Samples
Citation for this data set:
Emont MP, Jacobs C, Essene AL, Pant D et al. A single-cell atlas of human and mouse white adipose tissue. Nature 2022 Mar;603(7903):926-933. PMID: 35296864
Characterization of the stromal vascular fraction (SVF) of human subcutaneous adipose tissue (SAT)
Design: Excess adipose tissue from female subjects over the age of 18 undergoing elective plastic surgery procedures and free of other acute medical conditions was collected.
Organism: Homo sapiens
Type: Expression profiling by high throughput sequencing
36 Samples
Citation for this data set:
Emont MP, Jacobs C, Essene AL, Pant D et al. A single-cell atlas of human and mouse white adipose tissue. Nature 2022 Mar;603(7903):926-933. PMID: 35296864
Epigenomic and Transcriptional Basis of Human Insulin Resistance
Design: We performed RNA-seq on purified adipocytes collected from subcutaneous panniculus samples of 43 individuals in the first and 4th quartiles for HOMA-IR from a population of plastic surgery patients at BIDMC.
Organism: Homo sapiens
Type: Expression profiling by high throughput sequencing
43 Samples
Citation for this data set:
Emont MP, Jacobs C, Essene AL, Pant D et al. A single-cell atlas of human and mouse white adipose tissue. Nature 2022 Mar;603(7903):926-933. PMID: 35296864
Hepatic Interferon Regulatory Factor 3 Fuels Gluconeogenesis via PP2A-mediated Inactivation of AMP Kinase
Design: We report the IRF3 transcriptome and cistrome in primary mouse hepatocytes.
Organism: Mus musculus
Type: Expression profiling by high throughput sequencing;
Genome binding/occupancy profiling by high throughput sequencing
10 Samples
Citation for this data set:
Patel SJ, Liu N, Piaker S, Gulko A et al. Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of Ppp2r1b. Sci Transl Med 2022 Mar 23;14(637):eabh3831. PMID: 35320000
Adipocytes Fail to Maintain Cellular Identity During Obesity Due to Reduced PPARg Activity and Elevated TGFβ-SMAD Signaling
Design: Adipoq-NuTRAP mice fed chow or high fat diet were used for adipocyte-specific transcriptomic and epigenomic analysis.
Organism: Mus musculus
Type: Expression profiling by high throughput sequencing;
Genome binding/occupancy profiling by high throughput sequencing
13 Samples
Citation for this data set:
Roh HC, Kumari M, Taleb S, Tenen D et al. Adipocytes fail to maintain cellular identity during obesity due to reduced PPARγ activity and elevated TGFβ-SMAD signaling. Mol Metab 2020 Dec;42:101086. PMID: 32992037
Warming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity
Design: Ucp1-NuTRAP and Adipoq-NuTRAP mice exposed to different temperatures were used for brown, beige or white adipocyte-specific transcriptomic and epigenomic analysis.
Organism: Mus musculus
Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
58 Samples
Citation for this data set:
Roh HC, Tsai LTY, Shao M, Tenen D et al. Warming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity. Cell Metab 2018 May 1;27(5):1121-1137.e5. PMID: 29657031