15 posts

Congratulations to Greg Westcott on his newly awarded K08!

Congratulations to Greg Westcott on his newly awarded K08! It is titled Lymphatic-adipocyte interactions in obesity and lymphedema. The K08 will focus on specific mechanisms of the bidirectional relationship between adipocytes and lymphatic endothelial cells using metabolic and lymphatic vascular functional testing. It also includes single-nucleus RNA sequencing of adipose tissue hypertrophy associated with lymphatic diseases.

Suraj Patel shows hepatic IRF3 fuels dysglycemia in obesity through direct regulation of Ppp2r1b


Suraj Patel found that while global knockout of IRF3 reduces both liver insulin resistance and steatosis in obesity, hepatocyte-specific knockout of IRF3 in hepatocytes only affects insulin resistance. He was able to track a key target gene of IRF3 down: it’s Ppp2r1b, a component of the PP2A complex which affects AMPK and AKT signaling. This paper demonstrates that inflammation causes insulin resistance in liver by modulating signaling pathways that regulate gluconeogenesis. Read about it in Science Translational Medicine (Hepatic IRF3 Fuels Dysglycemia in Obesity Through Direct Regulation of Ppp2r1b. Science Translational Medicine, 2022; Mar 23;14(637):eabh3831. doi: 10.1126/scitranslmed.abh3831). Suraj’s paper was chosen for the cover image of the current issue Science Translational Medicine, seen here.