Herman MA, Rosen ED
GWAS have yielded many candidate loci for complex diseases like obesity, but interpreting the biological context of these findings has been difficult. Claussnitzer et al. (2015) use a sophisticated combination of bioinformatic and experimental approaches to address this bottleneck for variants in the FTO locus that associate with obesity.
Cell Metab. 2015 Oct 6;22(4):538-9. doi: 10.1016/j.cmet.2015.09.018
Jimenez MA, Akerblad P, Sigvardsson M, Rosen ED The Ebf (O/E) family of helix-loop-helix transcription factors plays a significant role in B lymphocyte and neuronal […]
Frankie D. Heyward, Nan Liu, Christopher Jacobs, Rachael Ivison, Natalia Machado, Aykut Uner, Harini Srinivasan, Suraj J. Patel, Anton Gulko, Tyler Sermersheim, Stuart H. Orkin, Linus Tsai, Evan D. Rosen AgRP neurons in the arcuate nucleus of the hypothalamus (ARC) coordinate homeostatic changes in appetite associated with […]
Roh HC, Tsai LT, Lyubetskaya A, Tenen D, Kumari M, Rosen ED Epigenomic mechanisms direct distinct gene expression programs for different cell types. Various in vivo tissues have […]
Mikkelsen TS, Xu Z, Zhang X, Wang L, Gimble JM, Lander ES, Rosen ED We report the generation and comparative analysis of genome-wide chromatin state maps, PPARγ and […]
