The single cell revolution has been going on for a few years, but adipocytes have lagged, because their large size and fragility make them unamenable to traditional whole cell approaches. Our (long and expensive!) optimization of single nucleus strategies for adipose tissue finally pays off. Read our paper (A single cell atlas of human and mouse white adipose tissue. Nature, 2022) in Nature to learn about the diversity of cell types in mouse and human adipose tissue, the discovery of several unique adipocyte subpopulations, and associations between these cells and metabolic diseases like T2D. Cells are featured across visceral and subcutaneous depots, as well as in leanness and obesity. This work was spearheaded by Margo Emont.
You may also like
Congratulations to Greg Westcott on his newly awarded K08! It is titled Lymphatic-adipocyte interactions in obesity and lymphedema. The K08 will focus […]
Congratulations to Suraj Patel on his newly awarded K08! The K08 will support Suraj’s research about the immunoregulation of hepatic metabolism.
Greg Westcott had a great review article about connections between lymphatics and adipose tissue in Endocrinology (Cross-talk between adipose and lymphatics in […]
Margo Emont wins Best Poster at the 2021 Broad Institute Retreat in the Genetics and Disease Biology category. The poster presented her […]