The single cell revolution has been going on for a few years, but adipocytes have lagged, because their large size and fragility make them unamenable to traditional whole cell approaches. Our (long and expensive!) optimization of single nucleus strategies for adipose tissue finally pays off. Read our paper (A single cell atlas of human and mouse white adipose tissue. Nature, 2022) in Nature to learn about the diversity of cell types in mouse and human adipose tissue, the discovery of several unique adipocyte subpopulations, and associations between these cells and metabolic diseases like T2D. Cells are featured across visceral and subcutaneous depots, as well as in leanness and obesity. This work was spearheaded by Margo Emont.
You may also like
Congratulations to Greg Westcott on his newly awarded K08! It is titled Lymphatic-adipocyte interactions in obesity and lymphedema. The K08 will focus […]
How does inflammation decrease adipose thermogenesis? Shuai Yan’s paper ( IRF3 Reduces Adipose Thermogenesis via ISG15-mediated Reprogramming of Glycolysis) in the Journal […]
This is a research career development award that provides funding for 3 years. Suraj has previously found that Interferon Regulatory Factor 3 (IRF3) […]
Farewell to two excellent technicians: Sam Piaker is headed to Dallas to manage Suraj Patel’s lab, and Molly Veregge is off to […]