How does inflammation decrease adipose thermogenesis? Shuai Yan’s paper ( IRF3 Reduces Adipose Thermogenesis via ISG15-mediated Reprogramming of Glycolysis) in the Journal of Clinical Investigation demonstrates one critical mechanism. Shuai showed that IRF3 in adipocytes drives a transcriptional program that includes ISG15, a ubiquitin-like molecule. ISG15 binds covalently to glycolytic enzymes, reducing lactate production, which is critical for thermogenesis.
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Congratulations to Suraj Patel on his newly awarded K08! The K08 will support Suraj’s research about the immunoregulation of hepatic metabolism.
Suraj Patel is moving to Dallas to start his own lab! Suraj is an Assistant Professor of Internal Medicine at UT Southwestern […]
This is a research career development award that provides funding for 3 years. Suraj has previously found that Interferon Regulatory Factor 3 (IRF3) […]